Zagotenemab ELISA Kit from ABBEXA LTD
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| Product Name | Zagotenemab ELISA Kit |
| Description | Zagotenemab ELISA Kit is a quantitative ELISA kit for detection of Zagotenemab. Zagotenemab is a humanized anti-tau antibody derived from MCI-1, Peter Davies' mouse monoclonal antibody against an early pathological conformation of tau. Zagotenemab binds and neutralizes soluble tau aggregates.Preclinical studies in tau transgenic mice showed that immunotherapy with MCI-1 reduced levels of hyperphosphorylated insoluble tau levels and neurofibrillary pathology (Chai et al., 2011).At the 2017 AAIC meeting, Lilly presented data from surface plasmon resonance binding and ELISA assays to assess LY3303560's selectivity to aggregates over monomer and characterize its epitope. LY3303560 reportedly had high affinity to soluble tau aggregate in vitro, at a KD of below 220 picomolar, compared to monomer, KD of 235 nanomolar. The antibody reportedly recognizes a conformational epitope whose primary epitope is in tau's N-terminal region. Intravenous administration to monkeys indicated clearance of 0.15 ml/h/kg and a half-life of 13 days. SC administration indicated a bioavailability of 79 percent, and rat CSF concentration was 0.1 percent of plasma at 24 hours after IV administration (Alam et al., 2017). Range: 0.31 ?g/ml - 5 ?g/ml. Sensitivity: 0.16 ?g/ml |
| Size | 96 tests, |
| Concentration | n/a |
| Applications | ELISA |
| Other Names | Zagotenemab, LY-3303560, 2019133-28-7, ELISA Zagotenemab, ELISA for Zagotenemab, ELISA kit Zagotenemab, ELISA kit for Zagotenemab, Enzyme-linked immunosorbent assay Zagotenemab, Human Zagotenemab, Zagotenemab ELISA, Zagotenemab ELISA kit, Zagotenemab Enzyme-linked immunosorbent assay, Human Zagotenemab ELISA, Human Zagotenemab ELISA kit, ELISA LY-3303560, ELISA for LY-3303560, ELISA kit LY-3303560, ELISA kit for LY-3303560, Enzyme-linked immunosorbent assay LY-3303560, Human LY-3303560, LY-3303560 ELISA, LY-3303560 ELISA kit, LY-3303560 Enzyme-linked immunosorbent assay, Human LY-3303560 ELISA, Human LY-3303560 ELISA kit, ELISA 2019133-28-7, ELISA for 2019133-28-7, ELISA kit 2019133-28-7, ELISA kit for 2019133-28-7, Enzyme-linked immunosorbent assay 2019133-28-7, Human 2019133-28-7, 2019133-28-7 ELISA, 2019133-28-7 ELISA kit, 2019133-28-7 Enzyme-linked immunosorbent assay, Human 2019133-28-7 ELISA, Human 2019133-28-7 ELISA kit |
| Gene, Accession, CAS # | CAS: 2019133-28-7 |
| Catalog # | abx395058 |
| Price | please inquire |
| Order / More Info | Zagotenemab ELISA Kit from ABBEXA LTD |
| Product Specific References | n/a |
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