C-646 from ARBOR ASSAYS, INC.

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Product NameC-646
DescriptionA reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding pocket. Demonstrates 86% inhibition against p300 at 10 nM. Less than 10% inhibition against serotonin N-acetyltransferase, PCAF, GCN5, Rtt109, Sas, and MOZ HATs in a chemical screening assay. Treatment of C3H 10T1/2 mouse fibroblasts at 25 uM results in an inhibitory effect against basal and TSA-inducible acetylation of histones H3 and H4. Shown to inhibit human cell growth in melanoma and non-small cell-lung cancer cell lines at 10 uM with similar or higher potency than peptide-based bisubstrate p300/CBP HAT inhibitor Lys-CoA-Tat at 25 uM.
Size5 mg
Concentration5 mg
ApplicationsActivator or Inhibitor
Other Namesp300 HAT inhibitor
Gene, Accession, CAS #n/a
Catalog #P014-5MG
Price$141.7
Order / More InfoC-646 from ARBOR ASSAYS, INC.
Product Specific Referencesn/a
ARBOR ASSAYS, INC.
ARBOR ASSAYS, INC.
ARBOR ASSAYS, INC.
1514 Eisenhower Place
Ann Arbor MI 48108-3284
P: 734-677-1774
F: 734-661-1884

info@ArborAssays.com

http://www.arborassays.com

Direct Order Fax Line: 734-677-6860


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