Recombinant Human ACVRL1-Fc Chimera (carrier-free) from BIOLEGEND

The transforming growth factor (TGF) superfamily controls a large number of biological responses and plays a prominent role during embryonic development, regulation of cell growth, differentiation, and apoptosis. Forty distinct TGF members have been identified in vertebrates and they are generally divided into two branches, the TGF/activin/nodal and the bone morphogenetic proteins (BMPs). The BMP family regulates embryogenesis and postnatal tissue homeostasis. BMP proteins signal through serine/threonine kinase receptors known as type I and type II receptors. Four type I receptors: BMPR1A (ALK3), BMPR1B (ALK6), ACVRL1 (ALK1), and ACVR1 (ALK2), and three type II receptors: BMPR2 (BMPRII), ACVR2A (ACTRIIA) and ACVR2B (ACTRIIB) mediate BMP signaling.

ACVRL1 is a type I cell-surface receptor for the Transforming Growth Factor beta (TGF beta) superfamily of ligands BMP-9 and BMP-10. BMP-9 binds ACVRL1 with high affinity, in association with BMPR2. Smad 1,5, 8 are preferentially phosphorylated and activated. Endoglin also acts as a co-receptor modulating signaling through ACVRL1. ACVRL1, predominantly expressed in endothelial cells, plays a key role in developmental and pathological angiogenesis.