PF-915275 from BIORBYT LTD.
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| Product Name | PF-915275 |
| Description | PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) (Ki 1 nM) with good preclinical pharmacokinetic properties.IC50 value: 1 nM (Ki)[2]Target: 11βHSD1in vitro: PF-915275 maintains potency in our cellular assay against human 11βHSD1 (HEK293, EC50 = 5 nM) and is selective against human 11βHSD2 (HEK293, 1.5% inhibition 10 µM). PF-915275 displays only weak affinity for the rodent choline transporter (Ki = 9.6 µM) and the hamster melatonin MT3 receptor (Ki = 9.6 µM) in the Cerep Bioprint screening panel. PF-915275 has good in vitro pharmacokinetic properties. In particular, PF-915275 is categorized as a low clearance compound (liver microsome assays) with high permeability (Caco2 assay). [2]in vivo: As a prelude to in vivo studies with PF-915275, the rat pharmacokinetic properties of this compound were determined. PF-915275 has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. [2]. MW: 350.3943 |
| Size | 1 g, 250 mg, 10 mg, 100 mg, 50 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | n/a |
| Gene, Accession, CAS # | CAS: 857290-04-1 |
| Catalog # | orb611853 |
| Price | please inquire |
| Order / More Info | PF-915275 from BIORBYT LTD. |
| Product Specific References | n/a |
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