Ponatinib, Free Base from BIORBYT LTD.
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| Product Name | Ponatinib, Free Base |
| Description | Ponatinib, Free Base. Ponatinib is also known as AP24534, is a multi-targeted tyrosine kinase inhibitor and is active against T315I and other BCR-ABL mutants. Ponatinib inhibited native BCR-ABL (IC50=0.37 nM) and the mutants with IC50 values of 2 nM (T315I); 0.44 nM (Q252H); 0.3 nM (Y253F); 0.3 nM (M351T); and 0.34nM (H396P) in biochemical assays. It also inhibited the growth of Ba/F3 cells with IC50 values of 0.5 nM (Native BCR-ABL), 11 nM (T315I), 2.2 nM (Q252H), 2.8 nM (Y253F), 1.5 nM (M351T), and 1.1 nM (H396P). It suppressed BCR-ABL(T315I)-driven tumor growth in mice and completely overcame resistance in cell-based mutagenesis screens. |
| Size | 500 mg, 250 mg, 200 mg, 100 mg, 50 mg, 25 mg, 5 g, 2 g, 1 g |
| Concentration | n/a |
| Applications | n/a |
| Other Names | n/a |
| Gene, Accession, CAS # | CAS: 943319-70-8 |
| Catalog # | orb153625 |
| Price | please inquire |
| Order / More Info | Ponatinib, Free Base from BIORBYT LTD. |
| Product Specific References | n/a |
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