Human MAGP-2 Protein from BIORBYT LTD.
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| Product Name | Human MAGP-2 Protein |
| Description | MAGP-2 (Microfibril-associated glycoProtein 2), also called MFAP5 (microfibrillar associated Protein 5) is a secreted, cell-associated 25 kDa mammalian member of the MFAP family of Proteins. Both MAGP-1 and MAGP-2 bind and covalently crosslink Fibrillin-1 and -2 through the Cys-rich binding domain. Functionally, the MAGP-2 RGD motif binds to the integrin alpha v beta 3, allowing cell attachment to microfibrils. MAGP?2 is thought to facilitate microfibril assembly and induce elastin fiber formation. Through its binding to EGF repeats, MAGP?2 mediates the metalloProteinase-dependent release of Jagged1, and the metalloProteinase-independent release of Notch extracellular domains. In endothelial cells, MAGP-2 promotes angiogenic sprouting by inhibiting Notch signaling, by binding to integrin alpha v beta 3 (which then enhances VEGF signaling), and/or enhancing the endothelial cell response to FGF basic and EGF. In ovarian cancer, MAGP-2 expression is associated with cancer cell survival, increased microvessel density, and poor prognosis. Purity 95.00%. MW: 43.7 kDa & 29.1 kDa |
| Size | 100 ug, 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | MAGP2,MAGP-2,MAGP2,MFAP-5,MFAP5,Microfibril-associated glycoprotein 2,MP25 |
| Gene, Accession, CAS # | NCBI: NP_003471.1 |
| Catalog # | orb1147015 |
| Price | $587 |
| Order / More Info | Human MAGP-2 Protein from BIORBYT LTD. |
| Product Specific References | n/a |
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