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Product Name | KDU691 |
Description | An antimalarial compound; inhibits the activity of recombinant P. vivax PI4K (IC50 = 1.5 nM); selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 µM, respectively), as well as VPS34 (IC50 = >9.7 µM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 µM); active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 µM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 µM, respectively); completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys at 20 mg/kg |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 1618681-91-6 KDU-691 Plasmodium PI-4K PI4K-βIII PI3K-α PI3Kβ PI3Kγ PI3Kδ VPS-34 anti-malarial |
Gene, Accession, CAS # | CAS: 1513879-19-0 |
Catalog # | 29019-10 |
Price | $336.00 |
Order / More Info | KDU691 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |