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Product Name | NVP-BEZ235 |
Description | A dual inhibitor of class I PI3Ks and mTOR (IC50s = 4, 75, 7, and 5 nM, for p110α, - β, -δ, and -γ, respectively) and mTOR (IC50 = 20 nM); selective for these enzymes over a panel of kinases (IC50s = >10 µM for all); inhibits proliferation of, and induces apoptosis in, MCF-7, MDA-MB-468, SK-BR-3, and MDA-MB-361 breast cancer cells at 0.1 or 1 µM; reduces tumor growth in a U87MG mouse xenograft model at 25, 35, or 45 mg/kg |
Size | 100 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Dactolisib |
Gene, Accession, CAS # | CAS: 915019-65-7 |
Catalog # | 10565-100 |
Price | $138.00 |
Order / More Info | NVP-BEZ235 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |