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Product Name | GDC-046 |
Description | A TYK2 inhibitor (Ki = 4.8 nM); selective for TYK2 over JAK1, -2, and -3 (Kis = 83.8, 27.6, and 253 nM, respectively); selectively inhibits TYK2-mediated IL-12-induced phosphorylation of STAT4 over JAK1-mediated IL-6-induced phosphorylation of STAT3 and JAK2-mediated erythropoietin-induced phosphorylation of STAT5 in cell-based assays (EC50s = 380, 2,000, and 1,700 nM, respectively) |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | GDC046 JAK2 JAK3 IL12 |
Gene, Accession, CAS # | CAS: 1258292-64-6 |
Catalog # | 36601-25 |
Price | $393.00 |
Order / More Info | GDC-046 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |