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Product Name | GS-39783 |
Description | A positive allosteric modulator of GABAB receptors; potentiates GABA-stimulated [35S]GTPγS binding to recombinant human GABAB receptors and rat cortical membranes (EC50s = 2.1 and 3.1 µM, respectively); amplifies GABAB receptor-mediated transient calcium signaling in HEK293 cells expressing human receptors (EC50 = 2.4 µM); suppresses alcohol self-administration in Indiana alcohol-preferring, Sardinian alcohol-preferring, and Alko Alcohol rats from 25-100 mg/kg; reduces amphetamine- or MK-801-induced hyperactivity in rats and the number of DOI-induced head twitches in mice; reduces the incidence of sound-induced tonic convulsions in juvenile mice (ED50 = 55.38 mg/kg) |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | GS39783 GABA-B GTPγ-S GTP-γS HEK-293 MK801 anti-psychotic |
Gene, Accession, CAS # | CAS: 39069-52-8 |
Catalog # | 29482-50 |
Price | $535.00 |
Order / More Info | GS-39783 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |