NG 25 (hydrochloride hydrate) from CAYMAN CHEMICAL COMPANY
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| Product Name | NG 25 (hydrochloride hydrate) |
| Description | An inhibitor of MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively); also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively); prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells at 100 nM; inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively, in Gen2.2 cells; decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells; reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1315355-93-1 NG25 MAP-4K2 MAP4K-2 TAK-1 p 38 TNFα IKK IκBα L-929 IFNα IFNβ CL-097 Gen 2.2 HCT-116-KRASWT KRASG13D CT26-KRASG12D 2108554-00-1 |
| Gene, Accession, CAS # | n/a |
| Catalog # | 27579-1 |
| Price | $54.00 |
| Order / More Info | NG 25 (hydrochloride hydrate) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY