Urocortin III (mouse) (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY

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Product NameUrocortin III (mouse) (trifluoroacetate salt)
DescriptionA neuropeptide hormone; expressed in the hypothalamus, brainstem, and LS/BnST as well as the small intestine, pancreatic β-cells, and skin in mice; selectively binds to type 2 CRF receptors (Kis = 5, 1.8, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively); stimulates cAMP production in CHO cells expressing rat CR2α and mouse CR2β (EC50s = 0.073 and 0.08 nM, respectively); increases exploration in the open field test and decreases latency to enter the lit compartment in the dark-light emergence test, indicating anxiolytic-like activity in mice (20 µg, i.c.v); co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro and in vivo in wild-type mice; depleted from β-cells in mouse and macaque models of type 2 diabetes,
Size500 µg
Concentrationn/a
Applicationsn/a
Other NamesCRF-2α -2β Spea 1 central nervous system
Gene, Accession, CAS #n/a
Catalog #24750-500
Price$459.00
Order / More InfoUrocortin III (mouse) (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY
Product Specific Referencesn/a
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640

Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com

http://www.caymanchem.com

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