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Product Name | (S)-Crizotinib |
Description | An MTH1 inhibitor (IC50 = 72 nM); selective for MTH1 over a panel of 456 kinases at 1 µM; induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 µM; induces ROS production and apoptosis in the same model; inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s = 0.52-7.4 µM); inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | SGC7901 BGC823 KRas p 53 SW 480 MTH |
Gene, Accession, CAS # | CAS: 1374356-45-2 |
Catalog # | 31114-5 |
Price | $107.00 |
Order / More Info | (S)-Crizotinib from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |