(S)-Crizotinib from CAYMAN CHEMICAL COMPANY
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| Product Name | (S)-Crizotinib |
| Description | An MTH1 inhibitor (IC50 = 72 nM); selective for MTH1 over a panel of 456 kinases at 1 µM; induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 µM; induces ROS production and apoptosis in the same model; inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s = 0.52-7.4 µM); inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | SGC7901 BGC823 KRas p 53 SW 480 MTH |
| Gene, Accession, CAS # | CAS: 1374356-45-2 |
| Catalog # | 31114-10 |
| Price | $164.00 |
| Order / More Info | (S)-Crizotinib from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY