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Product Name | EAI045 |
Description | A potent inhibitor of mutant EGFRs (IC50s = 0.076, 0.049, 0.002, and 1.6 µM for recombinant EGFRL858R, EGFRT790M, EGFRL858R/T790M, and wild-type EGFR, respectively); inhibits phosphorylation of EGFR in a concentration-dependent manner in H1975 cells; reduces proliferation of Ba/F3 cells expressing EGFRL858R/T790M and EGFRL858R/T790M/I941R from 0.01-10 µM; induces tumor regression and reduces EGFR signaling in mice bearing EGFRL858R/T790M, EGFRExon19del/T790M, and EGFRL858R/T790M/C797S tumors at 60 mg/kg/day with cetuximab, |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | EAI-045 EGFR-L858R T790M Exon19del I941R C797S H-1975 epidermal growth factor |
Gene, Accession, CAS # | CAS: 1942114-09-1 |
Catalog # | 19719-25 |
Price | $593.00 |
Order / More Info | EAI045 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |