TMI 1 from CAYMAN CHEMICAL COMPANY
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| Product Name | TMI 1 |
| Description | An ADAM and MMP inhibitor; inhibits ADAM17/TACE (IC50 = 8.4 nM in a cell-free enzyme assay); inhibits MMP-1, -2, -7, -9, -13, and -14, as well as ADAM-TS-4 in vitro (IC50s = 6.6, 4.7, 26, 12, 3, 26, and 100 nM, respectively); inhibits ADAM8, -10, -12, and -17/TACE (Kis = 21, 16, 1.8, and 0.079 nM, respectively, in cell-free enzyme assays); inhibits LPS-induced TNF-α secretion in Raw and THP-1 cells (IC50s = 40 and 200 nM, respectively), as well as in isolated human monocytes and whole blood (IC50s = 190 and 300 nM, respectively); inhibits the production of TNF-α ex vivo in synovium isolated from the inflamed joints of patients with rheumatoid arthritis (IC50s = 50 = 5 mg/kg) and reduces disease severity in mouse models of collagen-induced arthritis; decreases cell viability of (ED50s = 1.3-8.1 µM) and induces tumor apoptosis and reduces tumor growth in an MMTV-ErbB2/neu mouse model of breast cancer at 100 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | WAY-171318 WAY171318 TMI1 ADAM-17 MMP1 MMP2 MMP7 MMP9 MMP13 MMP14 ADAMTS ADAMTS4 ADAM8 ADAM10 ADAM12 THP1 TNFα caspase3 caspase7 MMTVErbB2 MMTVneu |
| Gene, Accession, CAS # | CAS: 287403-39-8 |
| Catalog # | 29713-10 |
| Price | $275.00 |
| Order / More Info | TMI 1 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY