GSK189254 from CAYMAN CHEMICAL COMPANY
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| Product Name | GSK189254 |
| Description | A histamine H3 receptor antagonist (Kis = 0.13, 0.68, and 1.74 nM for the recombinant human, rat, and mouse receptors, respectively); selective for the histamine H3 receptor over a panel of 50 receptors and ion channels at 1 µM; prevents imetit-induced decreases in forskolin-stimulated cAMP accumulation in HEK293-Gαo cells expressing the human histamine H3 receptor (pA2 = 9.06); inhibits intake R-(-)-α-methylhistamine-induced increases in water intake and reverses scopolamine-induced memory deficits in the passive avoidance test in rats; increases hindlimb grip force in a rat model of monoiodoacetate-induced osteoarthritic pain and increases the paw withdrawal threshold in a rat model of spinal nerve ligation-induced neuropathic pain (ED50s = 0.77 and 1.5 mg/kg, i.p., respectively) |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | GSK189254A |
| Gene, Accession, CAS # | CAS: 720690-73-3 |
| Catalog # | 36705-25 |
| Price | $382.00 |
| Order / More Info | GSK189254 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
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