NVP-BEP800 from CAYMAN CHEMICAL COMPANY
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| Product Name | NVP-BEP800 |
| Description | An Hsp90 inhibitor (IC50 = 58 nM for recombinant human Hsp90β); selective for Hsp90 over GRP94 and TRAP1 (IC50s = 4.1 and 5.5 µM, respectively); inhibits the growth of BT474, SK-BR-3, MCF-7, MDA-MB-157, MDA-MB-231, MDA-MB-468, and BT-20 breast cancer cells (GI50s = 53, 56, 118, 89, 190 173, and 162 nM, respectively); reduces levels of HER2 and Raf-1 in MCF-7 cells; induces apoptosis and attenuates X-ray-induced increases in Hsp70 levels in T98G glioblastoma cells; reduces tumor volume in A375 melanoma and BT474 breast cancer mouse xenograft models from 15-50 mg/kg; reduces tumor volume in an L1T2 Kaposi sarcoma mouse xenograft model |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NVPBEP800 NVPBEP 800 BEP 800 Hsp-90 90β 70 GRP 94 TRAP 1 BT 474 SKBR3 SKBR 3 BR3 MCF7 MDAMB157 MDAMB 157 MDAMB231 231 MDAMB468 468 BT20 HERr 2 A 375 L1 T2 |
| Gene, Accession, CAS # | CAS: 847559-80-2 |
| Catalog # | 18383-1 |
| Price | $78.00 |
| Order / More Info | NVP-BEP800 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY