Edit |   |
---|---|
Product Name | MSA-2 |
Description | A STING agonist; binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 µM, respectively); induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2'3'-cGAMP at 30 µM; reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression at 450 µg, intratumorally, and 50 mg/kg, s.c.; acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid |
Gene, Accession, CAS # | CAS: 129425-81-6 |
Catalog # | 30140-5 |
Price | $100.00 |
Order / More Info | MSA-2 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |