NVP-BGT226 from CAYMAN CHEMICAL COMPANY
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| Product Name | NVP-BGT226 |
| Description | A dual PI3K and mTOR inhibitor (EC50s = 4, 63, and 38 nM for PI3Kα, β, and γ isoforms, respectively, in a filter binding assay); binds to class I and class III PI3Ks (EC50s = 55.8 and 7.03 nM, for HsPI3Kβ and HsVps34, respectively); decreases protein levels of phosphorylated mTOR and Akt; inhibits the growth of squamous cell carcinoma cell lines, HONE-1, and a variant of HONE-1 resistant to cisplatin (IC50s = 7.4-27.8, 22.6, and 30.1 nM, respectively); inhibits tumor growth in a FaDu mouse xenograft model at doses of 2.5 and 5 mg/kg daily for three weeks |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 915020-55-2 1146702-67-1 1206911-15-0 NVP-BGT-226 NVPBGT-226 BGT-226 BGT226 NYP-BGT-226 NYPBGT-226 NYPBGT226 PI-3-K HsVps-34 HONE1 G-0 G-1 NVPBGT226 PI3-K PI3Kβ PI3Kγ SCC |
| Gene, Accession, CAS # | CAS: 1245537-68-1 |
| Catalog # | 22142-1 |
| Price | $40.00 |
| Order / More Info | NVP-BGT226 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY