XL388 from CAYMAN CHEMICAL COMPANY
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| Product Name | XL388 |
| Description | An orally bioavailable and ATP-competitive inhibitor of mTOR (IC50 = 9.9 nM); selective for mTOR over a panel of more than 140 kinases, including various PI3Ks (IC50s = >3,000 nM); inhibits mTORC1 and mTORC2 in vitro (IC50s = 8 and 166 nM, respectively); induces cytotoxicity in MG-63, U2OS, and Saos-2 osteosarcoma and 786-0 kidney cancer cells and increases apoptosis in 786-0 and MG-63 cells; induces cell cycle arrest at the G1 phase and increases autophagy in MG-63 cells; reduces tumor growth in an MCF-7 breast cancer mouse xenograft model at 50 and 100 mg/kg; inhibits phosphorylation of mTORC1 and mTORC2 substrates p70S6K, S6, 4E-BP1, and Akt in MCF-7 and PC-3 xenograft tumors at 100 mg/kg; reduces tumor growth in U2OS and 786-0 mouse xenograft models at 20 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1777807-51-8 XL-388 mTORC-1 2 MG63 U2-OS Saos2 MCF7 PC3 p70S6-K S-6 4EBP1 |
| Gene, Accession, CAS # | CAS: 1251156-08-7 |
| Catalog # | 20237-10 |
| Price | $230.00 |
| Order / More Info | XL388 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY