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Product Name | JTE-607 |
Description | A cytokine synthesis inhibitor; inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human PBMCs (IC50s = 11, 5.9, 8.8, 7.3m and 9.1 nM, respectively); binds to CPSF3 in cell-free assays; induces accumulation of CXCL8 pre-mRNA in LPS-stimulated SC cells; reduces LPS-induced mortality in a C. parvum-sensitized mouse model of endotoxic shock from 0.3-10 mg/kg, i.v. |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 188791-71-1 JTE607 TNFα IL1β IL6 IL8 IL10 CPSF CXCL Cryptosporidium |
Gene, Accession, CAS # | CAS: 188791-09-5 |
Catalog # | 36942-25 |
Price | $289.00 |
Order / More Info | JTE-607 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |