IPI-549 from CAYMAN CHEMICAL COMPANY
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| Product Name | IPI-549 |
| Description | An inhibitor of PI3Kγ (IC50s = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively); selective for PI3Kγ over a panel of 468 mutant and nonmutant protein and lipid kinases and a panel of G protein-coupled receptors, ion channels, and transporters at 10 µM; inhibits migration of BMDMs (IC50 = 85 nM); sensitizes doxorubicin-resistant SW620/Ad300 cells to P-gp substrates, such as paclitaxel (IC50s = 710 and 6.7 nM for paclitaxel alone and in combination with IPI-549, respectively); enhances the tumor growth reduction of paclitaxel in an SW620/Ad300 mouse xenograft model at 3 mg/kg in combination with paclitaxel |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | IPI549 PI3K-γ α β δ SKOV-3 S-473 RAW264.7 SW-620 Ad-300 Pgp AKTS473 |
| Gene, Accession, CAS # | CAS: 1693758-51-8 |
| Catalog # | 26416-10 |
| Price | $223.00 |
| Order / More Info | IPI-549 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY