STX140 from CAYMAN CHEMICAL COMPANY
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| Product Name | STX140 |
| Description | An estrogen sulfamate with anticancer activities; inhibits steroid sulfatase (IC50s = 39 and 0.5 nM in placental microsomes and MCF-7 cancer cells, respectively); binds to carbonic anhydrase IX and II (Kis = 70 and 270 nM, respectively); inhibits bovine brain tubulin assembly in a cell-free assay (IC50 = 2.2 µM) and tubule formation in HUVECs at 50 and 100 nM; inhibits proliferation of LNCaP, PC3, and MDA-MB-231 cancer cells, as well as wild-type A2780 cancer cells and adriamycin- and cisplatin-resistant A2780 cancer cells (IC50s = 530, 400, 618, 330, 870, and 380 nM, respectively); reduces angiogenesis in a Matrigel™ plug assay in mice and tumor growth in MCF-7 and MDA-MB-231 mouse xenograft models at 20 mg/kg |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 2-Methoxyestradiol-bis-sulphamate |
| Gene, Accession, CAS # | CAS: 401600-86-0 |
| Catalog # | 27863-5 |
| Price | $324.00 |
| Order / More Info | STX140 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY