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Product Name | MRTX-0902 |
Description | An inhibitor of the SOS1-K-RasG12C protein-protein interaction (Ki = 1.9 nM); selective for the SOS1-K-RasG12C protein-protein interaction over the SOS1-K-Ras protein-protein interaction (IC50 = >10,000 nM); decreases phosphorylated ERK levels in MNK1 cancer cells (IC50 = 29 nM); reduces tumor volume and phosphorylated ERK levels when combined with MTX-849 in a PaCa-2 pancreatic cancer mouse xenograft model at 25 or 50 mg/kg twice per day |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | SOS1KRasG12C SOS1 KRasG12C SOS 1 KRas MTX849 PaCa2 MRTX0902 MRTX902 902 |
Gene, Accession, CAS # | CAS: 2654743-22-1 |
Catalog # | 38578-10 |
Price | $450.00 |
Order / More Info | MRTX-0902 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |