TMI-005 from CAYMAN CHEMICAL COMPANY
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| Product Name | TMI-005 |
| Description | An inhibitor of ADAM17/TACE, MMP-1, and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively); inhibits LPS-induced TNF-α release in isolated human whole blood (IC50 = 144 ng/ml); reduces basal and ionizing radiation-induced secretion of ALCAM and amphiregulin from A549 and NCI H125 cells at 25 µM; inhibits proliferation of A549 at 25 and 50 µM; sensitizes A549 and NCI H125 cells to ionizing radiation at 25 µM; reduces tumor growth in an A549 mouse xenograft model when administered at 25 mg/kg twice per day in combination with ionizing radiation |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Apratastat |
| Gene, Accession, CAS # | CAS: 287405-51-0 |
| Catalog # | 29016-5 |
| Price | $183.00 |
| Order / More Info | TMI-005 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY