JTE-013 from CAYMAN CHEMICAL COMPANY
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| Product Name | JTE-013 |
| Description | An S1P2 and S1P4 receptor antagonist (IC50 = 17 and 237 nM, respectively); selective for S1P2 over S1P1 and S1P3 (IC50s = >10 µM for both); reverses S1P-induced inhibition of HUVEC and SMC migration at 1 and 10 µM; reverses S1P-induced inhibition of B16 murine melanoma cell migration; reduces lung injury, endothelial dysfunction, and pulmonary edema in a rat model of cecal ligation and puncture-induced sepsis at 30 mg/kg; inhibits DES1 (IC50 = 16.8 µM), as well as SK1 and SK2 (IC50s = 25.1 and 4.3 µM, respectively) |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | reverses inhibition inhibits coronary artery smooth muscles lipids cells proliferation cytoskeletal morphogenesis GPCRs protein-coupled receptors antagonists S1P2 humans rats EDG5 sphingosines sphingosine-1-phosphates sphingosine1 inhibitors JTE013 FDG-5 cancers |
| Gene, Accession, CAS # | CAS: 383150-41-2 |
| Catalog # | 10009458-1 |
| Price | $26.00 |
| Order / More Info | JTE-013 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY