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Product Name | NG 25 (hydrochloride hydrate) |
Description | An inhibitor of MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively); also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively); prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells at 100 nM; inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively, in Gen2.2 cells; decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells; reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 1315355-93-1 NG25 MAP-4K2 MAP4K-2 TAK-1 p 38 TNFα IKK IκBα L-929 IFNα IFNβ CL-097 Gen 2.2 HCT-116-KRASWT KRASG13D CT26-KRASG12D 2108554-00-1 |
Gene, Accession, CAS # | n/a |
Catalog # | 27579-10 |
Price | $308.00 |
Order / More Info | NG 25 (hydrochloride hydrate) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |