NGP-555 from CAYMAN CHEMICAL COMPANY
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| Product Name | NGP-555 |
| Description | A modulator of γ-secretase that inhibits AICD cleavage to Aβ (IC50s = 531 and 131 nM for Aβ40 and Aβ42, respectively, in HeLa cell membranes); selective for AICD cleavage to Aβ over E-cadherin and Notch cleavage to E-cadherin γ-C-terminal fragments and NICD, respectively, at 30 µM; reduces cortical and hippocampal plaque area in Tg2576 mice at ~50 mg/kg per day; decreases plasma and brain Aβ40 and Aβ42 levels, as well as increases spontaneous alternations in the Y-maze in Tg2576 mice at 25 mg/kg per day |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NGP555 Aβ 40 42 Tg 2576 |
| Gene, Accession, CAS # | CAS: 1304630-27-0 |
| Catalog # | 27918-1 |
| Price | $117.00 |
| Order / More Info | NGP-555 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY