NVP-AEW541 from CAYMAN CHEMICAL COMPANY
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| Product Name | NVP-AEW541 |
| Description | An IGF-1R inhibitor (IC50 = 0.15 µM in a cell-free assay); selective for IGF-1R over a panel of 20 kinases but also inhibits InsR, FLT1, FLT3, and Tie2 (IC50s = 0.14, 0.6, 0.42, and 0.53 µM, respectively, in cell-free assays); selectively inhibits the autophosphorylation of IGF-1R over InsR, EGFR, PDGFR, c-Kit, and Bcr-Abl in cells (IC50s = 0.086, 2.3, >10, >10, >5, and >10 µM, respectively); reduces tumor volume in an NWT-21 murine fibrosarcoma model at 20, 30, or 50 mg/kg twice per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | IGF1R NVPAEW541 NVP-AEW-541 NVPAEW VEG-FR1 FLT Tie estimated glomerular filtration rate Platelet-derived growth factor receptors ckit BcrAbl NWT21 benzyloxyphenyl Azetidin-yl)methyl 2320261-63-8 |
| Gene, Accession, CAS # | CAS: 475489-16-8 |
| Catalog # | 33946-5 |
| Price | $111.00 |
| Order / More Info | NVP-AEW541 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY