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Product Name | COG133 (trifluoroacetate salt) |
Description | A peptide fragment of ApoE and an α7 nAChR antagonist (IC50 = 720 nM); suppresses TNF-α and NO release in BV-2 microglia from 10-50 µM; reduces LPS-induced increases in brain levels of TNF-α and IL-6 in mice; decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact at 203 and 406 µg/kg; delays disease onset and reduces disease severity in a mouse model of EAE at 1 mg/kg |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Ac-LRVRLASHLRKLRKRLL-NH2|ApoE (133-149) |
Gene, Accession, CAS # | CAS: 514200-66-9 |
Catalog # | 33587-1 |
Price | $108.00 |
Order / More Info | COG133 (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |