Edit |   |
---|---|
Product Name | Upadacitinib |
Description | A JAK1 inhibitor (IC50 = 47 nM); selective for JAK1 over JAK3 and Tyk2 (IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, ROCK1, and ROCK2 (IC50s = 120, 920 and 430 nM, respectively); decreases cytokine-induced STAT phosphorylation in a variety of human cells (IC50s = 1.6-649 nM); reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis at 1, 3, and 10 mg/kg twice per day for 17 days |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ABT-494 |
Gene, Accession, CAS # | CAS: 1310726-60-3 |
Catalog # | 29706-25 |
Price | $381.00 |
Order / More Info | Upadacitinib from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |