NVP-BKM120 from CAYMAN CHEMICAL COMPANY
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| Product Name | NVP-BKM120 |
| Description | An inhibitor of the class I PI3K isoforms p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM); selective for these isoforms over the class III PI3K Vps34 (IC50 = 2,410 nM), mTOR (IC50 = 2,866 nM), PI4Kβ (IC50 = >25,000 nM), and a variety of kinases (IC50s = >10,000 nM); inhibits proliferation of human tumor and glioma cell lines, with p53 wild-type glioma cells more sensitive than p53 mutant/deleted glioma cells (IC50s = 1.28 and 2.08 µM, respectively); crosses the blood brain barrier; increases survival in a U87 glioma mouse xenograft intracranial tumor model when orally administered at 20 and 40 mg/kg once per week |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Buparlisib |
| Gene, Accession, CAS # | CAS: 944396-07-0 |
| Catalog # | 11587-25 |
| Price | $102.00 |
| Order / More Info | NVP-BKM120 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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