Edit |   |
---|---|
Product Name | LOXO-292 |
Description | A RET kinase inhibitor; inhibits phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM); selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary thyroid and CCDC6-RET gene fusion-positive TPC-1 thyroid cancer cells, by 20 to 1,700-fold; improves survival in a CCDC6-RET gene fusion positive orthotopic PDX mouse model of brain cancer at 30 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ARRY-192|Selpercatinib |
Gene, Accession, CAS # | CAS: 2152628-33-4 |
Catalog # | 33515-5 |
Price | $49.00 |
Order / More Info | LOXO-292 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |