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Product Name | 20-carboxy Arachidonic Acid |
Description | 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B.{14780} Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 µM) and PPARγ (Kd = 1.7 ± 0.5 µM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.{14780} |
Size | 50 µg |
Concentration | n/a |
Applications | n/a |
Other Names | 20-carboxy AA|20-COOH-AA |
Gene, Accession, CAS # | CAS: 79551-84-1 |
Catalog # | 10007912-50 |
Price | $424.00 |
Order / More Info | 20-carboxy Arachidonic Acid from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |