Urocortin III (mouse) (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY
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| Product Name | Urocortin III (mouse) (trifluoroacetate salt) |
| Description | A neuropeptide hormone; expressed in the hypothalamus, brainstem, and LS/BnST as well as the small intestine, pancreatic β-cells, and skin in mice; selectively binds to type 2 CRF receptors (Kis = 5, 1.8, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively); stimulates cAMP production in CHO cells expressing rat CR2α and mouse CR2β (EC50s = 0.073 and 0.08 nM, respectively); increases exploration in the open field test and decreases latency to enter the lit compartment in the dark-light emergence test, indicating anxiolytic-like activity in mice (20 µg, i.c.v); co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro and in vivo in wild-type mice; depleted from β-cells in mouse and macaque models of type 2 diabetes, |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | CRF-2α -2β Spea 1 central nervous system |
| Gene, Accession, CAS # | n/a |
| Catalog # | 24750-1 |
| Price | $689.00 |
| Order / More Info | Urocortin III (mouse) (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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