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Product Name | FSL-1 (trifluoroacetate salt) |
Description | A synthetic lipopeptide agonist of TLR2/TLR6; increases NF-κB activity by 4- and 8-fold in HEK293 cells transfected with TLR2 and TLR6 but not TLR6 alone at 0.1 and 1 nM, respectively; induces the expression of the CCL20, IL-8, IL-1β, and TNF-α in THP-1 cells and, to a lesser extent, in TLR10 knockdown cells at 100 ng/ml; dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing CXCL10 when administered in combination with IFN-γ with a maximal increase of 50% at 0.5-50 µg/ml; induces fever and increases plasma levels of IL-6 and TNF-α by greater than 90-fold in rats at 100 µg/kg, i.p.; dose-dependently reduces locomotor activity and both food and water consumption with a maximal reduction of ten grams per 12 hours at 10-1,000 µg/kg, i.p. |
Size | 500 µg |
Concentration | n/a |
Applications | n/a |
Other Names | FSL1 TLR-2 6 10 HEK-293 NFκB CCL-20 IL8 IL1β TNFα DM-13 VMM-1 CXCL-10 IL6 IFNγ THP1 322455-70-9 |
Gene, Accession, CAS # | n/a |
Catalog # | 24220-500 |
Price | $97.00 |
Order / More Info | FSL-1 (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |