Amyloid Beta Pyroglutamate 3-42 Pre-Formed Fibrils from EAGLE BIOSCIENCES INC.
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| Product Name | Amyloid Beta Pyroglutamate 3-42 Pre-Formed Fibrils |
| Description | Our Amyloid Beta pyroglutamate 3-42 (pyro AB) Pre-formed Fibrils are generated from Amyloid Beta Peptide 3-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) using a previously published method. Our pyro AB3-42 fibrils present as primarily long strands when observed under TEM and AFM, and have a unique high molecular weight signal on a Western Blot with an anti-amyloid beta antibody. Amyloid beta peptide (AB) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques. The accumulation of AB plaques in the brain is considered a hallmark of Alzheimer's disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation. Pyroglutamate AB 3-42 is an N-terminally truncated peptide species that is modified by glutaminyl cyclase and has been reported to compromise 15-45% of total amyloid beta deposits in brains of AD patients. Pyroglutamate AB 3-42 exhibits higher aggregation propensity and neurotoxicity compared with full-length AB 1-42 and is an active target in the next generation AD therapeutic development. |
| Size | 100 ug |
| Concentration | n/a |
| Applications | RUO |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | SPR-492B |
| Price | $580 |
| Order / More Info | Amyloid Beta Pyroglutamate 3-42 Pre-Formed Fibrils from EAGLE BIOSCIENCES INC. |
| Product Specific References | n/a |
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
20A NW Blvd., Suite 112
Nashua NH 03063
P: 617-419-2019
P: 866-411-8023
F: 617-419-1110
info@EagleBio.com
http://www.EagleBio.com
Profile of EAGLE BIOSCIENCES INC.