Active Human Recombinant Tau (K18), P301L mutant Protein Monomer, 100 µg from EAGLE BIOSCIENCES INC.

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Product NameActive Human Recombinant Tau (K18), P301L mutant Protein Monomer, 100 µg
DescriptionAlzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
Size100 µg
Concentrationn/a
ApplicationsRUO
Other Namesn/a
Gene, Accession, CAS #n/a
Catalog #SPR-328B
Price$525
Order / More InfoActive Human Recombinant Tau (K18), P301L mutant Protein Monomer, 100 µg from EAGLE BIOSCIENCES INC.
Product Specific Referencesn/a
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
20A NW Blvd., Suite 112
Nashua NH 03063
P: 617-419-2019
P: 866-411-8023
F: 617-419-1110

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