Human Synthetic Amyloid Beta 1-42 Oligomers from EAGLE BIOSCIENCES INC.

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Product Name	Human Synthetic Amyloid Beta 1-42 Oligomers
Description	Our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published. Our Aβ42 oligomers present as globular oligomers when observed under TEM and AFM, and have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody. Our Aβ42 oligomers were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer's disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation. Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function. Aβ oligomers generated in vitro were toxic to PC12 cells and SH-SY5Y cells. Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson's disease patients with dementia.
Size	100 ug
Concentration	n/a
Applications	RUO
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	SPR-488B
Price	$815
Order / More Info	Human Synthetic Amyloid Beta 1-42 Oligomers from EAGLE BIOSCIENCES INC.
Product Specific References	n/a

EAGLE BIOSCIENCES INC.

EAGLE BIOSCIENCES INC.
20A NW Blvd., Suite 112
Nashua NH 03063
P: 617-419-2019
P: 866-411-8023
F: 617-419-1110

info@EagleBio.com

http://www.EagleBio.com

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