Human Recombinant Tau-352 (fetal 0N3R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils, from EAGLE BIOSCIENCES INC.
Search, find, compare suppliers for Human Recombinant Tau-352 (fetal 0N3R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils, products.
| Edit | |
|---|---|
| Product Name | Human Recombinant Tau-352 (fetal 0N3R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils, |
| Description | Brain-specifc tau isoforms vary in the number of N-terminal inserts and C-terminal repeat domains due to alternative splicing of exons; only the shortest isoform of tau, 0N3R, is expressed in the fetal brain during neurogenesis. Tau and alpha-synuclein polymerized into amyloid fibrils to form filamentous inclusions in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Tau has been shown to interact with alpha-synuclein in vitro, with synergistic cross-seeding between tau and alpha-synuclein resulting in polymerization of each other into fibrillary amylid lesions in neuronal cultures and in vivo. Recombinant tau and alpha-synuclein co-polymer fibrils have demonstrated a more widespread transmission of induced pathology in a rodent model of tauopathies compared to pure Tau or alpha-synuclein fibrils alone. These co-polymer fibrils have also shown enhanced alpha-synuclein aggregations in vitro, and more sever alpha-synuclein pathology and Parkinson's disease-like symptoms in mice. |
| Size | 100 ug |
| Concentration | n/a |
| Applications | RUO |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | SPR-494B |
| Price | $965 |
| Order / More Info | Human Recombinant Tau-352 (fetal 0N3R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils, from EAGLE BIOSCIENCES INC. |
| Product Specific References | n/a |
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
20A NW Blvd., Suite 112
Nashua NH 03063
P: 617-419-2019
P: 866-411-8023
F: 617-419-1110
info@EagleBio.com
http://www.EagleBio.com
Profile of EAGLE BIOSCIENCES INC.