Human Recombinant Alpha Synuclein S87N Mutant Pre-formed Fibrils from EAGLE BIOSCIENCES INC.
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| Product Name | Human Recombinant Alpha Synuclein S87N Mutant Pre-formed Fibrils |
| Description | Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse a-syn (MsWT) is faster than wild-type human a-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing pathology of endogenous mouse a-syn. A53T or S87N substitutions in human a-syn sustantially accelerate fibrilization rates in vitro. Chimeric HuS87N fibrils show enhanced pathogenicity to wild-type mouse neurons, greater than HuWT, HuA53T, and MsWT fibrils. HuS87N fibrils can be used as a more human-like alternative to MsWT fibrils to induce equivalent or greater endogenous a-syn seeding and pahtology in wild-type mice. |
| Size | 100 ug |
| Concentration | n/a |
| Applications | RUO |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | SPR-500B |
| Price | $510 |
| Order / More Info | Human Recombinant Alpha Synuclein S87N Mutant Pre-formed Fibrils from EAGLE BIOSCIENCES INC. |
| Product Specific References | n/a |
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
20A NW Blvd., Suite 112
Nashua NH 03063
P: 617-419-2019
P: 866-411-8023
F: 617-419-1110
info@EagleBio.com
http://www.EagleBio.com
Profile of EAGLE BIOSCIENCES INC.