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Product Name | CpG-B DNA (ODN 2006), Human/ Mouse |
Description | Approximately 200 nmol lyophilized, purified 24-mer CpG ODN. ODN 2006 is a prototype of the class of CpG-B oligodeoxynucleotides (ODN), also known as 'K'-type ODN, with a full phosphorothioate (PS) backbone. It is particularly effective for activating B cells. The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. The Toll-like receptor-9 (TLR9, CD289) appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways including the mitogen activated protein kinase (MAPKs) and NFκB, leading to stimulation of various cells of the immune system. The human TLR9 is expressed in B cells and plasmacytoid dendritic cells (PDC). Mice also express TLR9 in the myeloid compartment. Optimal sequences for activati |
Size | 200 nmol |
Concentration | n/a |
Applications | Functional studies. RUO |
Other Names | n/a |
Gene, Accession, CAS # | n/a |
Catalog # | HC4039-200nmol |
Price | $488 |
Order / More Info | CpG-B DNA (ODN 2006), Human/ Mouse from HYCULT BIOTECH |
Product Specific References | n/a |