Edit |   |
---|---|
Product Name | HNP1-3, Human, Natural |
Description | Human neutrophil alpha-defensins (Human Neutrophil Peptides, HNP) belong to the family of cationic trisulfide-containing microbicidal peptides. Three highly homologous human defensins stored in azurophilic granules of polymorphonuclear leukocytes (PMN), HNP 1-3, account for about 5% of total PMN protein and comprise about 99% of the total defensin content of the neutrophils with traces of HNP-4. HNP-1, HNP-2 and HNP-3 are encoded by two genes DEFA1 and DEFA3 localized to chromosome 8. Number of gene copies substantially varies between individuals with complete lack of the DEFA3 allele in 10% subjects. DEFA1 and DEFA3 encode identical peptides except the conversion of the first amino acid from alanine in HNP-1 to aspartic acid in HNP-3; HNP-2 represent N-terminally truncated iso-form lacking the first amino acid. HNP 1-3 are capable to kill and/or inactivate a broad spectrum of bacteria, fungi or some enveloped viruses and have recently been shown to exert the anti-HIV activity produced |
Size | 100 µg |
Concentration | n/a |
Applications | Functional studies. RUO |
Other Names | n/a |
Gene, Accession, CAS # | n/a |
Catalog # | HC4014-100UG |
Price | $488 |
Order / More Info | HNP1-3, Human, Natural from HYCULT BIOTECH |
Product Specific References | n/a |