Edit |   |
---|---|
Product Name | sMAdCAM-1, Human, ELISA kit |
Description | Range: 0.4-100 ng/ml. The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a cell-surface Ig superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain and a short cytoplasmatic domain. It interacts via its N-terminal Ig domain with the lymphocyte homing receptor integrin alpha4beta7. MAdCAM-1 promotes the adhesion of T and B cells, monocytes/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium and is critical for lymphocyte homing to the gut. RNA transcripts are predominantly expressed in the small intestine, mesenteric lymph nodes, colon and spleen. MAdCAM-1 transcripts are weakly expressed in human pancreas and brain. The MAdCAM-1 protein (60 kDa) is widely expressed on endothelia in both lymphoid and non-lymphoid tissues. Furthermore, it is expressed in thymic medulla and on high endothelial venules (HEV). This expression increases upon response to several cyt |
Size | 1 x 96 det. |
Concentration | n/a |
Applications | RUO |
Other Names | n/a |
Gene, Accession, CAS # | n/a |
Catalog # | HK337-01 |
Price | $973 |
Order / More Info | sMAdCAM-1, Human, ELISA kit from HYCULT BIOTECH |
Product Specific References | n/a |