CpG-C DNA (ODN 2395), Human/ Mouse from HYCULT BIOTECH
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| Product Name | CpG-C DNA (ODN 2395), Human/ Mouse |
| Description | Approximately 200 nmol lyophilized, purified 22-mer CpG ODN. ODN 2395 is a prototype of the class of CpG-C oligodeoxynucleotides (ODN) and is particularly effective at activating B- and NK cells and inducing IFN-alpha production in vitro of human peripheral blood mononuclear cells (PBMC). The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. The Toll-like receptor-9 (TLR9, CD289) appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways including the mitogen activated protein kinase (MAPKs) and NFκB, leading to stimulation of various cells of the immune system. The human TLR9 is expressed in B cells and plasmacytoid dendritic cells (PDC). Mice also express TLR9 in the myeloid compartment. O |
| Size | 200 nmol |
| Concentration | n/a |
| Applications | RUO |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | HC4041-200nmol |
| Price | $488 |
| Order / More Info | CpG-C DNA (ODN 2395), Human/ Mouse from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
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