CpG-A DNA (ODN 2216), Human/Mouse from HYCULT BIOTECH
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| Product Name | CpG-A DNA (ODN 2216), Human/Mouse |
| Description | Approximately 200 nmol lyophilized, purified 20-mer CpG ODN. ODN 2216 is a prototype of the class of CpG-A oligodeoxynucleotides (ODN), also known as ‘D’-type ODN, and contains a phosphodiester (PO) backbone. It is particularly effective for activating NK cells and inducing IFN-alpha production in plasmacytoid dendritic cell (PDC) precursors. The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. The Toll-like receptor-9 (TLR9, CD289) appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways including the mitogen activated protein kinase (MAPKs) and NFκB, leading to stimulation of various cells of the immune system. The human TLR9 is expressed in B cells and PDC. Mice also expres |
| Size | 200 nmol |
| Concentration | n/a |
| Applications | Functional studies. RUO |
| Other Names | n/a |
| Gene, Accession, CAS # | n/a |
| Catalog # | HC4037-200nmol |
| Price | $488 |
| Order / More Info | CpG-A DNA (ODN 2216), Human/Mouse from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
Profile of HYCULT BIOTECH