Complement factor I, Human, ELISA kit from HYCULT BIOTECH

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Product NameComplement factor I, Human, ELISA kit
DescriptionCFI is a protein of the complement system (serine protease) , also known as as C3b/C4f inactivator, and is a protein that is encoded by the CFI gene located on chromosome 4. It regulates complement activation by cleaving cellbound or fluid phase C3b and C4b. CFI is synthesised predominantly in the liver, and is initially secreted as a single 88 kDa gene product; this precursor protein is then cleaved by furin to yield the mature CFI protein, which is a disulfide-linked dimer of heavy chain residues (residue 19-335, 51 kDa) and light chain (residues 340-583, 37 kDa). Only the mature protein is active. Genetic polymorphism in CFI has been observed (variants R201S, R406H, R502L). CFI deficiency leads to low levels of complement component 3 (C3) in plasma, due to unregulated activation of the complement alternative pathway, and it has been associated with recurrent bacterial infections in children. More recently, mutations in the CFI gene have been shown to be implicated in development of Haemolytic Uremic Syndrome, a renal disease also caused by unregulated complement activation. Cross Reactivity: Mouse - No , Pig - No , Rat - No
Size2 x 96 det.
Concentrationn/a
ApplicationsImmunoassay
Other NamesCFI, C3b-Inactivator, C3b/C4b inactivator, Konglutinogen-Activating Factor Sandwich ELISA kit, EIA, enzyme immunoassay, assay
Gene, Accession, CAS #n/a
Catalog #HK355-02
Price$1268
Order / More InfoComplement factor I, Human, ELISA kit from HYCULT BIOTECH
Product Specific Referencesn/a
HYCULT BIOTECH
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353

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