Stable SH-SY5Y Cell Line - HFE, C282Y Variant from KERAFAST, INC.

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Product Name	Stable SH-SY5Y Cell Line - HFE, C282Y Variant
Description	Source: Human Brain. Cell type: Neuroblastoma (SH-SY5Y).
Size	1 vial
Concentration	n/a
Applications	n/a
Other Names	n/a
Gene, Accession, CAS #	Accession: Q30201
Catalog #	EQ1003
Price	$532
Order / More Info	Stable SH-SY5Y Cell Line - HFE, C282Y Variant from KERAFAST, INC.
Product Specific References	Lee SY et al. Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE. FASEB J. 2007. 21(2):564-576. Lee SY, Liu S, Mitchell RM, Slagle-Webb B, Hong Y, Sheehan JM, and Connor JR. HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A. International Journal of Cancer 2011. 129:2104-2114. Liu Y, Lee SY, Neely E, Nandar W, Moyo M, Simmons Z, Connor JR. Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. JBC 2011. 286(15):13161-13170. Wang XS, Lee S, Simmons Z, Boyer P, Scott K, Liu W, Connor J. Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. J Neurol Sci. 2004 Dec 15;227(1):27-33. F. Ali-Rahmani, P. Grigson, S. Lee, E. Neely, J.R Connor, and C-L. Schengrund. H63D mutation in HFE alters cholesterol metabolism and induces memory impairment. Neurobiol. Aging. 2014. 35(6):1511.e1-1511.e12. Fatima Ali-Rahmani, Michael A. Huang, C-L. Schengrund, James R. Connor, and Sang Y. Lee. C282Y-HFE Gene Variant Affects Cholesterol Metabolism in Human Neuroblastoma Cells. PLoS ONE. 2014. 9(2):e88724.

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