IP3R, R3 Expressing HEK-293 Cell Line (HEKR3) from KERAFAST, INC.

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Product NameIP3R, R3 Expressing HEK-293 Cell Line (HEKR3)
DescriptionImmortalized cell lines (HEK-293), with all three isotypes of the inositol 1,4,5-trisphosphate receptor (IP3R) knocked out, or which express a single IP3R subtype or combinations of two subtypes.
Size1 vial
Concentrationn/a
Applicationsn/a
Other Namesn/a
Gene, Accession, CAS #Accession: Q14643, Q14571, Q14573, CVCL_HB82, CVCL_HB83, CVCL_HB84, CVCL_HB85, CVCL_HB86, CVCL_HB87, CVCL_HB88
Catalog #EUR033
Price$658
Order / More InfoIP3R, R3 Expressing HEK-293 Cell Line (HEKR3) from KERAFAST, INC.
Product Specific References
  1. Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE 2nd, Van Petegem F, Yule DI. Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release. Sci Signal. 2016 Apr 5;9(422):ra35.
  2. Thillaiappan NB, Chavda AP, Tovey SC, Prole DL, Taylor CW. Ca(2+) signals initiate at immobile IP(3) receptors adjacent to ER-plasma membrane junctions. Nat Commun. 2017 Nov 15;8(1):1505. View Article
  3. Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M. TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca(2+) Transfer. Curr Biol. 2018 Feb 5;28(3):369-382.e6. View Article
  4. Mataragka S, Taylor CW. All three IP(3) receptor subtypes generate Ca(2+) puffs, the universal building blocks of IP(3)-evoked Ca(2+) signals. J Cell Sci. 2018 Aug 10. pii: jcs.220848. View Article
  5. Atakpa P, Thillaiappan NB, Mataragka S, Prole DL, Taylor CW. IP(3) Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca(2+) to Lysosomes. Cell Rep. 2018 Dec 11. View Article
  6. Ellefsen KL, Lock JT, Settle B, Karsten CA, Parker I. Applications of FLIKA, a Python-based image processing and analysis platform, for studying local events of cellular calcium signaling. Biochim Biophys Acta Mol Cell Res. 2018 Nov 27. View Article
  7. Atakpa P, van Marrewijk LM, Apta-Smith M, Chakraborty S, Taylor CW. GPN does not release lysosomal Ca(2+), but evokes ER Ca(2+) release by increasing cytosolic pH independent of cathepsin C. J Cell Sci. 2019 Jan 7. View Article
  8. Lock JT, Alzayady KJ, Yule DI, Parker I. All three IP(3) receptor isoforms generate Ca(2+) puffs that display similar characteristics. Sci Signal. 2018 Dec 18;11(561). pii: eaau0344. View Article
  9. Lock JT, Parker I. IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release. Elife. 2020 May 12;9:e55008.  View Article
  10. Lagos-Cabré R, Ivanova A, Taylor CW. Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle. Cell Rep. 2020 Dec 15;33(11):108483. View article
KERAFAST, INC.
KERAFAST, INC.
KERAFAST, INC.
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